Spicy Cajun Chicken Alfredo

Featured in: Comfort Food Classics

This dish combines tender chicken breasts coated in Cajun seasoning, pan-seared to golden perfection, and served over al dente fettuccine. The creamy Alfredo sauce is infused with garlic, smoked paprika, and optional chili flakes for a flavorful kick. A touch of Parmesan and fresh parsley garnish enhance the balance of spice and richness. Perfect for those who enjoy a comforting yet boldly seasoned meal.

Updated on Sat, 15 Nov 2025 10:57:00 GMT
Steaming plate of Spicy Cajun Chicken Alfredo featuring tender chicken and creamy Alfredo sauce. Save
Steaming plate of Spicy Cajun Chicken Alfredo featuring tender chicken and creamy Alfredo sauce. | suggestionsforever.com

A bold, creamy pasta dish featuring tender Cajun-spiced chicken tossed with fettuccine in a rich Alfredo sauce, perfect for spice lovers.

The first time I made this Spicy Cajun Chicken Alfredo, I was surprised at how quickly it came together and how the entire family wanted seconds. Combining the warmth of Cajun spice with the richness of a classic Alfredo has made it our go-to for cozy nights in.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts, 2 tablespoons Cajun seasoning, 1 tablespoon olive oil
  • Pasta: 340 g (12 oz) fettuccine
  • Alfredo Sauce: 2 tablespoons unsalted butter, 3 cloves garlic (minced), 1 cup (240 ml) heavy cream, 1 cup (100 g) freshly grated Parmesan cheese, 1/2 teaspoon smoked paprika, 1/2 teaspoon chili flakes (optional for extra heat), salt and black pepper (to taste)
  • Garnishes: 2 tablespoons chopped fresh parsley, extra grated Parmesan cheese

Instructions

Cook Pasta:
Cook the fettuccine according to package instructions in salted boiling water until al dente. Reserve 1/2 cup pasta water, then drain and set aside.
Season Chicken:
While the pasta cooks, pat chicken breasts dry and coat them evenly with Cajun seasoning.
Cook Chicken:
Heat olive oil in a large skillet over medium-high heat. Add chicken and cook 5 6 minutes per side or until fully cooked and golden brown. Remove chicken from the skillet, let rest for 5 minutes, then slice thinly.
Make Sauce:
In the same skillet, reduce heat to medium and add butter. Sauté minced garlic for 1 minute until fragrant.
Finish Alfredo:
Stir in heavy cream, smoked paprika, and chili flakes. Bring to a gentle simmer, then whisk in Parmesan cheese until melted and sauce is smooth. Season with salt and pepper.
Toss Pasta:
Add cooked fettuccine to the sauce, tossing to coat. If needed, add reserved pasta water a little at a time for a silkier sauce.
Assemble and Serve:
Top pasta with sliced Cajun chicken. Garnish with chopped parsley and extra Parmesan. Serve immediately.
Creamy Fettuccine Alfredo with spicy Cajun chicken beautifully arranged and ready to be enjoyed. Save
Creamy Fettuccine Alfredo with spicy Cajun chicken beautifully arranged and ready to be enjoyed. | suggestionsforever.com

My kids love helping sprinkle the Cajun seasoning and watching the cheese melt into the sauce while the kitchen fills with the aroma of garlic and spice. Sharing this meal always brings smiles to our table.

Serving Suggestions

Pair this pasta with a crisp green salad and garlic bread for a satisfying meal. A glass of chilled white wine, such as Sauvignon Blanc, is a wonderful complement to the dish's heat and creaminess.

Variations

Try swapping fettuccine for penne or linguine, or reduce the heat by omitting chili flakes. For a lighter version, substitute half-and-half instead of heavy cream.

Storing and Reheating

Leftovers keep well in an airtight container in the fridge for up to 3 days. Reheat gently on the stove with a splash of milk or cream to keep the sauce smooth.

Close-up image of flavorful Spicy Cajun Chicken Alfredo with vibrant parsley garnish, a delicious meal. Save
Close-up image of flavorful Spicy Cajun Chicken Alfredo with vibrant parsley garnish, a delicious meal. | suggestionsforever.com

This easy Spicy Cajun Chicken Alfredo brings bold flavor and creamy comfort to your dinner table. Enjoy every spicy, cheesy bite!

Recipe Help & FAQs

How do I ensure the chicken stays tender?

Pat the chicken dry before seasoning and cook over medium-high heat to seal juices. Let it rest before slicing to retain moisture.

Can I adjust the spice level?

Yes, increase or decrease Cajun seasoning and chili flakes to suit your preferred heat intensity.

What can I use instead of fettuccine?

Penne, linguine, or other pasta shapes work well and will absorb the sauce nicely.

How do I make the sauce creamier?

Add reserved pasta water gradually while tossing the pasta to achieve a silkier, smoother sauce.

Is there a lighter alternative for the cream?

Substitute heavy cream with half-and-half for a lighter sauce without compromising much creaminess.

Spicy Cajun Chicken Alfredo

Creamy fettuccine with tender Cajun-seasoned chicken and a spicy, rich Alfredo sauce.

Prep Time
15 mins
Time to Cook
25 mins
Overall Time
40 mins
Created by Suggestions Forever Hannah Lewis


Skill Level Medium

Cuisine American (Cajun-inspired, Italian-American)

Makes 4 Serving Count

Diet Details None specified

Ingredient List

Chicken

01 2 large boneless, skinless chicken breasts
02 2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 cup heavy cream
04 1 cup freshly grated Parmesan cheese
05 1/2 teaspoon smoked paprika
06 1/2 teaspoon chili flakes (optional)
07 Salt and black pepper to taste

Garnishes

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese

Directions

Step 01

Cook pasta: Prepare fettuccine in salted boiling water according to package directions until al dente. Reserve 1/2 cup pasta water, drain and set aside.

Step 02

Season chicken: Pat chicken dry and evenly coat with Cajun seasoning.

Step 03

Sear chicken: Heat olive oil in large skillet over medium-high heat. Cook chicken 5-6 minutes per side until cooked through and golden. Remove, rest 5 minutes, then slice thinly.

Step 04

Prepare sauce base: Reduce skillet heat to medium. Melt butter, then sauté minced garlic for 1 minute until fragrant.

Step 05

Create Alfredo sauce: Add heavy cream, smoked paprika, and optional chili flakes. Simmer gently, whisk in Parmesan until smooth. Season with salt and pepper.

Step 06

Combine pasta and sauce: Toss cooked fettuccine in sauce, adding reserved pasta water gradually for desired consistency.

Step 07

Assemble and serve: Arrange sliced Cajun chicken atop pasta. Garnish with parsley and extra Parmesan. Serve immediately.

Needed Equipment

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons

Allergy Notice

Review each ingredient to check for allergens. Ask a healthcare specialist if you're unsure.
  • Contains dairy (butter, cream, Parmesan cheese)
  • Contains gluten (fettuccine)
  • May contain mustard or celery from Cajun seasoning

Nutrition Info (per serving)

Details shown are for reference. Always check with your healthcare provider for advice.
  • Calories: 610
  • Fats: 27 g
  • Carbohydrates: 54 g
  • Proteins: 38 g