01 - Heat oven to 350°F (175°C) and grease a 9x13-inch baking dish.
02 - Cook elbow macaroni in a large pot of salted boiling water until al dente. Drain and set aside.
03 - Melt 4 tablespoons butter in a saucepan over medium heat. Whisk in flour and cook, stirring, for 1-2 minutes until lightly golden.
04 - Gradually pour in whole milk while whisking to avoid lumps. Add salt, black pepper, ground mustard, and nutmeg; continue cooking, stirring constantly, until thickened.
05 - Remove pan from heat. Add sharp cheddar, mozzarella, and Parmesan cheeses. Stir until well combined and smooth.
06 - Fold drained macaroni into cheese sauce, ensuring even coating.
07 - Spread macaroni mixture in prepared baking dish. Evenly sprinkle panko breadcrumbs over top and drizzle with melted butter.
08 - Bake uncovered for 25-30 minutes until the topping is golden brown and the filling bubbles.
09 - Allow to cool for 5 minutes before serving warm.